To retrieve the samples, Krebs hires Zora Bennett (Scarlett Johansson), a covert operations expert known for her experience with high-risk missions. Zora puts together a team for the job. She brings in Duncan Kincaid (Mahershala Ali), a friend and a seasoned field leader, along with LeClerc (Bechir Sylvain), Nina (Philippine Velge), and Bobby Atwater (Ed Skrein). Also joining them is Dr. Henry Loomis (Jonathan Bailey), a paleontologist brought in for his knowledge of dinosaur behavior and biology.
Meanwhile, sailing nearby is Reuben Delgado (Manuel Garcia-Rulfo) with her daughters, Isabella (Audrina Miranda) and Teresa (Luna Blaise), and Teresa’s boyfriend, Xavier (David Iacono). When their boat drifts too close to the island, they are attacked by a Mosasaurus. Their vessel is destroyed and they become stranded in open water.
Zora and Kincaid’s team finds the shipwrecked family and rescues them. But with no way to send them back to safety, the team takes the family with them as they move forward with the mission.
Once they set foot on the island, they realize the difficulty of this mission. The island is crawling with more aggressive and terrifying creatures. Among them is a monstrous, genetically altered dinosaur called the Distortus rex. It is probably the most brutal creature on the island.