"Lilo & Stitch" is about a troubled girl named Lilo (Daveigh Chase). She lives in Hawaii with her sister, Nani (Tia Carrere), and finds it difficult to make friends at school. Until she met Stitch (Chris Sanders), a blue alien space dog.
Stitch is an experiment, an abomination with a propensity for chaos. He is also a fugitive who happens to fall to Earth accidentally. Despite all of these, the young girl still adopted him, as she believes that there is something good inside him.
Meanwhile, the Grand Councilwoman (Zoe Caldwell) employs the mad scientist Dr. Jumba Jookiba (David Ogden Stiers) and Earth specialist Agt. Wendell Pleakley (Kevin McDonald) to re-capture Stitch. And hence, a cat and mouse chase begins.